Core Platform

Proprietary Platform Technology & Diversified Pipeline

At the core of MediWound’s innovation is a proprietary platform based on a unique mixture of proteolytic enzymes, enriched in bromelain— derived from the stem of the pineapple plant. Using our exclusive enzyme enrichment technology, these bioactive compounds are carefully extracted, purified, and enhanced to achieve maximum therapeutic potential.

This platform serves as the foundation for both our approved product and our entire pipeline of biologic therapies in development. With multiple mechanisms of action, bromelain offers broad clinical applicability across various therapeutic areas.

Our mission is to lead a paradigm shift toward non-surgical solutions that redefine standards of care, with a current focus on therapies that promote and accelerate tissue repair.

When topically applied to burns or wounds, the enzymes selectively break down non-viable tissue while leaving healthy, viable tissue unharmed.

Plant to Drug

MediWound’s proprietary process is designed to preserve and amplify the natural efficacy of bromelain—from plant harvest to final pharmaceutical product—ensuring consistency, potency, and reliability at every stage.

Publications

NexoBrid®

Cost – effectiveness
Cost – effectiveness
Cost Saving vs SOC
Minic J, Vestita M, et al.
Economic analysis of enzymatic debridement versus standard burn care: a retrospective analysis. Ann ...
Link to pdf article
Major clinical benefits
Major clinical benefits
Genital Burns
Schulz A, et al.
Treatment of genital burn injuries: traditional procedures and new techniques. Adv Skin Wound Care. ...
Link to pdf article
Unmet need
Unmet need
Putting Down The Knife
Edmondson SJ, et al.
Time to start putting down the knife: A systematic review of burns excision tools of randomised and ...
Link to pdf article
Clinical Guidelines
Clinical Guidelines
EBA Guidelines
European Burn Association.
EBA guidelines for burn care. Version 4. 2017.
Link to pdf article
Major clinical benefits
Major clinical benefits
Compartment Syndrome
Krieger Y, et al.
Escharotomy with an enzymatic debridement agent for treating experimental burn-induced compartment s...
Link to pdf article
Major clinical benefits
Major clinical benefits
Face Burns
Schulz A, et al.
Enzymatic debridement of deeply burned faces: Healing and early scarring based on tissue preservatio...
Link to pdf article
Clinical studies
Clinical studies
DETECT Phase III Study
Shoham Y, et al.
Early enzymatic burn debridement: results of the DETECT multicenter randomized controlled trial. J B...
Link to pdf article
Market Experience
Market Experience
>10 Years of Experience
Shoham Y, et al.
Bromelain-based enzymatic burn debridement: A systematic review of clinical studies on patient safet...
Link to pdf article
Clinical studies
Clinical studies
Clinical Trials Review
Rosenberg L, et al.
Minimally invasive burn care: a review of seven clinical studies of rapid and selective debridement ...
Link to pdf article
Clinical studies
Clinical studies
Enzymatic Debridement Study
Rosenberg L, et al.
A novel rapid and selective enzymatic debridement agent for burn wound management: a multi-center RC...
Link to pdf article
Major clinical benefits
Major clinical benefits
Hand Burns
Malsagova AT, et al.
Long-term functional outcomes following enzymatic debridement of deep hand burns using Nexobrid®: a ...
Link to pdf article
Clinical studies
Clinical studies
Pediatric Study
Shoham Y, et al.
Open label RCT of the efficacy and safety of NexoBrid compared to SOC in children with burns. Burns....
Link to pdf article
Clinical Guidelines
Clinical Guidelines
EU Consensus Guidelines
Hirche C, et al.
Eschar removal by bromelain-based enzymatic debridement (Nexobrid®) in burns: European consensus gui...
Link to pdf article
Unmet need
Unmet need
Excision Limitations
Gurfinkel R, et al.
Histological assessment of tangentially excised burn eschars. Can J Plast Surg. 2010 Fall;18(3):e33-...
Link to pdf article
Clinical studies
Clinical studies
Chronic Wounds
Shoham Y, et al.
Bromelain-based enzymatic debridement of chronic wounds: A preliminary report. Int Wound J. 2018 Oct...
Link to pdf article
Clinical Guidelines
Clinical Guidelines
WHO BMCI Guidelines
World Health Organization.
WHO guidelines for burn wound care. Geneva: World Health Organization; 2022.
Link to pdf article

EscharEx®

Clinical studies
Clinical studies
WBP and Healing Correlation
Carter, M et al.
Wound Bed Preperation and Wound Closure in Venous Leg Ulcers: A Post Hoc Analysis of the ChronEx Mul...
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Pre Clinical
Pre-Clinical
Comparison to SANTYL
Shoham Y, et al.
Development of a porcine hard-to-heal wound model: evaluation of a bromelain-based enzymatic debridi...
Link to pdf article
Mechanism of action
Mechanism of action
Effect on Biofilm
Watters CM, et al.
Enzymatic degradation of in vitro Staphylococcus aureus biofilms supplemented with human plasma. Inf...
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Mechanism of action
Mechanism of action
Mechanism of Action
Snyder RJ, et al.
Bromelain-based enzymatic debridement: mechanism of action in the wound environment. A literature re...
Link to pdf article
Clinical studies
Clinical studies
EscharEx vs. SANTYL
Dove CY, et al.
Bromelain versus collagenase-based debridement in venous leg ulcers: post-hoc analysis of ChronEx Tr...
Link to pdf article
Clinical studies
Clinical studies
PharmEx Study
Snyder RJ, et al.
An open-label, proof-of-concept study assessing the effects of bromelain-based enzymatic debridement...
Link to pdf article
Clinical studies
Clinical studies
EscharEx: VLU, DFU
Shoham Y, et al.
Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized control...
Link to pdf article
Clinical studies
Clinical studies
ChronEx Study Results
Kirsner RS, et al.
Safety and efficacy of a bromelain-based enzymatic debridement agent for venous leg ulcers: a random...
Link to pdf article